CBD oil for pain relief

All products derived from the Cannabis sativa plant are referred to as cannabis, including two highly active cannabinoids, cannabidiol (CBD) and tetrahydrocannabinol (THC). Unlike THC, CBD is not psychoactive, which makes an appealing option for those seeking pain relief without THC's “high” or potential abuse dependence. Despite lack of FDA approval, oil gaining popularity a remedy chronic pain, insomnia, anxiety. Two main cannabinoid receptors (CB1 CB2) can be found throughout central nervous system, immune function cells, GI tract. Cannabinoids act agonists, binding CB1 CB2 create analgesic effect. This process stronger with THC than CBD, there debate on exactly how provides relief. Originally thought indirectly affect CB2, has been shown have direct agonistic activity many cell-surface receptors, serotonin 1A receptor (5-HT1A), adenosine A2A receptor, peroxisome proliferator-activated gamma (PPAR-γ) receptor. These all associated anti-inflammatory pathways. also produces supraspinal analgesia through indirect antagonism N-methyl-d-aspartate (NMDAR) inhibiting sigma 1 (σ1R), which, when antagonized, block G-protein-coupled 55 (GPCR55) activation NMDAR. modulates various pathways involved in inflammation, though more studies needed confirm current research. Research pharmacodynamic pharmacokinetic properties that expand use cannabinoids medical therapy. particular, studied its beneficial applications anxiety, cancer among other conditions. Several clinical confirmed CBD's therapeutic efficacy treatment epilepsy, adverse effects chemotherapy, loss appetite weight HIV/AIDS. A 2020 study published Pharmaceuticals presented results comparative analysis assessing differences effectiveness safety THC-dominant, CBD-dominant, combination treatments patients cancer. The researchers significant improvements patient intensity, affective sensory sleep quality duration, distress, both physical psychological symptom burden three treatments. Somewhat surprisingly, were no between their effects. evidence CBD-dominant useful cancer-related symptoms. Systematic reviews randomized controlled trials by National Academy Sciences concluded effective tool managing pain. demonstrated at least modest 22 out 29 safe alternative management. finding was consistent across most studies. recent systematic review trials, predominately double-blind, indicated effect compared placebo. authorized cannabis any but approved several drugs contain cannabinoids. manufactured diluting carrier like coconut olive oil. readily available pharmacies grocery stores marketed capsules, lotions, gummies. wide range oral doses reported, suggested 25 mg 30 daily Counsel modestly relieving well tolerated does produce mental impairments typically THC. Adverse rare may include nausea, fatigue, irritability. Caution interact certain medications increase level blood thinner coumadin same manner grapefruit juice.